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Old Main (Vassar College), a National Historic Landmark building on the campus of Vassar College in Poughkeepsie, New York (New York)
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Old Main (Minot State University), a building on the campus of Minot State University in Minot, North Dakota. (North Dakota)
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Old Main (Nicholas County High School), listed on the NRHP in West Virginia (West Virginia)
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Old Main, Suomi College, the first building on the campus of Suomi College (now Finlandia University) in Hancock, Michigan. The building is listed on the National Register of Historic Places. (Michigan)
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Old Main (Knox College), the only existing site of the 1858 senatorial debates between Abraham Lincoln and Stephen Douglas, in Illinois (Illinois)
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Old Main (University of Arkansas), the first building on the campus of the University of Arkansas in Fayetteville, Arkansas (Arkansas)
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